A3D3 develops customized AI solutions to process large datasets in real time, addressing challenges in high-energy physics, multi-messenger astrophysics, and systems neuroscience. Their work spans processing extreme-rate particle collisions, rapidly identifying astrophysical events across multiple messengers, and enabling real-time closed-loop neural experiments. They are a multi-disciplinary and geographically distributed team that collaborates with scientists across domains, forming a central hub of excellence for innovation in accelerated AI for science. Their approach is to tightly couple AI algorithm innovations, heterogeneous computing platforms, and science-driven application development. A3D3 develops AI strategies accelerated by emerging processor technology, and employing hardware-AI co-design. The work is extended to the public through a diverse set of educational training programs and by mentoring next-generation scientists.